Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | — |
| Reactant | HCID 57565924 | HCID 57565924 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68956475 | HCID 68956475 | 23.9% |
Reaction Steps
To the mixture of 6-chlorooxindole (10 g, 60 mmol) and 1-(4-chloro-2-formyl-phenoxy)-cyclobutanecarboxylic acid methyl ester (18 g, 67 mmol) in methanol (100 mL) was added pyrrolidine (4.5 mg, 63 mmol) dropwise. The mixture was then heated at 80° C. for 1 h. After cooled to room temperature, the mixture was filtered and the precipitate was collected, dried to give the title compound (6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08076482B2 |
|---|
| Source dataset | uspto-grants-2011_12 |
|---|
| ORD ID | ord-5a7f826094cc4dee989b7dcb24f11184 |
|---|
| Source note | uspto-grants-2011_12 |
|---|
