Pyrrolidine → HCID 86632061, compound

Participants

Reaction Conditions

Reaction Steps

To the mixture of 6-chloro-1,3-dihydro-indol-2-one (10 g, 60 mmol) and (4-chloro-2-formyl-phenoxy)-acetic acid methyl ester (15.2 g, 67 mmol) in methanol (100 mL) was added pyrrolidine (4.5 g, 63 mmol) dropwise. The mixture was then heated at 80° C. for 1 h. After cooled to room temperature, the mixture was filtered and resulting precipitate was collected, dried to give the title compound as a yellow solid (12 g).

Provenance & Evidence