反应详情

温度

60 °C

To 75% aqueous acetic acid (1000 ml) was slowly added trityl olmesartan medoxomil (110 gms) [prepared as described in example 5] at 25-30° C. The contents were stirred at 60° C. for 1 hour. The reaction mass was chilled to 0-5° C. and filtered to remove tritanol. The reaction mass was concentrated under reduced pressure. The residue was quenched with water (500 ml), neutralized with a base and extracted in dichloromethane (500 ml). The clear dichloromethane extract was then concentrated under reduced pressure and stripped off with acetone. The residue thus obtained was isolated from the acetone (250 ml) to give 55 gms of the title compound. Chromatographic purity->99%.

1. customat 25-30° C
2. temperatureThe reaction mass was chilled to 0-5° C.
3. filtrationfiltered
4. customto remove tritanol
5. concentrationThe reaction mass was concentrated under reduced pressure
6. customThe residue was quenched with water (500 ml)
7. extractionextracted in dichloromethane (500 ml)
8. extractionThe clear dichloromethane extract
9. concentrationwas then concentrated under reduced pressure
10. customThe residue thus obtained