Ethanolamine → 1-(4-Chloro-3-trifluoromethylphenyl)-3-{4-[2-(2-hydroxy-ethylamino)-pyrimidin-4-yloxy]-phenyl}-urea

Participants

Reaction Steps

A mixture of 144 mg (0.296 mmol) 1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-phenyl]-urea, 40 mg (0.65 mmol) 2-aminoethanol and 5 ml THF was stirred at r.t. for 12 h. The reaction mixture was evaporated and the residue purified by chromatography on silica (dichloromethane/ethanol 96:4). Yield 56 mg (40%) of the title compound.

Provenance & Evidence