3-Amino-1-propanol → HCID 24997344, compound

Participants

Reaction Steps

A mixture of 71 mg (0.145 mmol) 1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[2-chloro-4-(2-methanesulfonyl-pyrimidin-4-yloxy)-phenyl]-urea, 23 mg (0.30 mmol) 3-amino-propan-1-ol and 2 ml THF was stirred at r.t. for 12 h. The reaction mixture was evaporated and the residue purified by chromatography on silica (dichloromethane/ethanol 96:4). Yield 21 mg (28%) of the title compound.

Provenance & Evidence