Benzenamine, 2-chloro-5-(trifluoromethyl)- → HCID 24997947, compound

Participants

Reaction Steps

105 mg (0.65 mmol) 1,1′-Carbonyl-diimidazol (CDI) was given to a solution of 115 mg (0.59 mmol) 2-chloro-5-(trifluoromethyl)aniline in 4.0 ml dichloromethane. After stirring for 12 h at r.t. a solution of 220 mg (0.59 mmol) [4-(4-Amino-phenoxy)-pyrimidin-2-yl]-(3-trimethylsilanyloxy-propyl)-amine in 6 ml dichloromethane within 30 min. was added and the mixture stirred for 5 d at r.t. A solution of 1.4 ml (1.4 mmol) 1 M tetrabutylammonium fluoride in THF was given to the mixture and stirring continued for 12 h. The reaction mixture was evaporated and the residue was purified by chromatography on silica gel (dichloromethane/ethanol 96:4). Yield: 6 mg (2%) of the title compound.

Provenance & Evidence