HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylsulfanyl-6-(4-nitro-phenoxy)-pyrimidine → 4-(6-Methylsulfanyl-pyrimidin-4-yloxy)-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylsulfanyl-6-(4-nitro-phenoxy)-pyrimidine | HCID 67523929 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran ethanol | HCID 21873804 | — |
| Product | 4-(6-Methylsulfanyl-pyrimidin-4-yloxy)-phenylamine | HCID 67523901 | — |
Reaction Steps
A solution of 4-methylsulfanyl-6-(4-nitro-phenoxy)-pyrimidine (0.5 g, 1.9 mmol) in ethanol/THF (25 ml, 1:1) is added catalyst (10% Pd/C, 0.3 g, 0.28 mmol). The starting material is hydrogenated at 4 bar for 4 h at r.t. The catalyst is filtered off and the solvent is removed. Due to instability, the product is used without any further purification for the subsequent reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08080552B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-2c7650bacd224ed498aae6791f0ed950 |
| Source note | uspto-grants-2011_12 |