Ethanolamine → HCID 24998584, compound

HRID 659029Notes

Reaction equation

HRID 659029 reaction equation
CS([C:5]1[N:10]=[CH:9][N:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=3)=[O:20])=[CH:14][CH:13]=2)[CH:6]=1)(=O)=O.[NH2:32][CH2:33][CH2:34][OH:35]>ClCCl>[OH:35][CH2:34][CH2:33][NH:32][C:5]1[N:10]=[CH:9][N:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=3)=[O:20])=[CH:14][CH:13]=2)[CH:6]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 67523930HCID 67523930, compound

Product 1

HCID 24998584HCID 24998584, compoundYield 53.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
110 °C

Procedure

A solution of 1-[4-(6-methanesulfonyl-pyrimidin-4-yloxy)-phenyl]-3-(3-trifluoromethyl-phenyl)-urea (100 mg, 0.22 mmol) in dichloromethane (1 ml) and 2-aminoethanol (133 μl, 2.2 mmol) is sealed in a reaction tube and heated in the microwave at 110° C. for 15 minutes. The reaction mixture is evaporated and purified by preparative HPLC to yield 51 mg (53%) of a white powder.

Workup

  1. customThe reaction mixture is evaporated
  2. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-bce07be6a37a4e1596ba1e4cc5542217
Source dataset
uspto-grants-2011_12
Patent number
US08080552B2

Reaction notes

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