HRID65903

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(Cl)c1cc(C(=O)Cl)cc([N+](=O)[O-])c1

HCID83451

5-Nitroisophthaloyl chloride

C8H3Cl2NO4

HCID517045

Sodium Acetate

C2H3NaO2

结构：Nc1cc2ccc(S(=O)(=O)O)cc2cc1S(=O)(=O)[O-].[Na+]

HCID23702076

2,7-Naphthalenedisulfonic acid, 3-amino-, sodium salt (1:1)

C10H8NNaO6S2

PRODUCTS

生成物

结构：O=C(Nc1cc2ccc(S(=O)(=O)[O-])cc2cc1S(=O)(=O)[O-])c1cc(C(=O)Nc2cc3ccc(S(=O)(=O)[O-])cc3cc2S(=O)(=O)[O-])cc([N+](=O)[O-])c1.[Na+].[Na+].[Na+].[Na+]

HCID131711362

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

2 次

PROCEDURE

实验过程

A 6.5 g portion of 3-amino-2,7-naphthalenedisulfonic acid monosodium salt is suspended in 100 ml of water and the pH is adjusted to 7.5-8.0 giving a solution. A 1.82 g portion of sodium acetate is added and dissolved and 2.75 g of 5-nitro-1,3-benzenedicarbonylchloride is added. A 100 ml portion of water is added to maintain solution and the reaction is allowed to stand overnight. The mixture is treated with activated carbon and concentrated to about 50 ml on a rotary evaporator. The solid which forms is redissolved by heating on a steam bath. Cooling produces crystals which are dried overnight in an Abderhalden under high vacuum and refluxing toluene to give 3,3'-[(5-nitro-1,3-phenylene)bis(carbonylimino)]bis[2,7-naphthalenedisulfonic acid] tetrasodium salt.

WORKUP

后处理

dissolutiondissolved
temperatureto maintain solution
additionThe mixture is treated with activated carbon
concentrationconcentrated to about 50 ml on a rotary evaporator
dissolutionThe solid which forms is redissolved
temperatureby heating on a steam bath
temperatureCooling
customproduces crystals which
customare dried overnight in an Abderhalden under high vacuum
temperaturerefluxing toluene

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ddaf2aeebe944b5282aa00472c27ec11
来源数据集: uspto-grants-1978_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04129591
来源说明: uspto-grants-1978_12

反应 SMILES

[Na+:1].[NH2:2][C:3]1[C:4]([S:17]([O-:20])(=[O:19])=[O:18])=[CH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[C:8]([S:13]([OH:16])(=[O:15])=[O:14])[CH:7]=2.[C:21]([O-])(=O)[CH3:22].[Na+].[N+:26]([C:29]1[CH:30]=[C:31]([C:38](Cl)=[O:39])[CH:32]=[C:33]([C:35](Cl)=[O:36])[CH:34]=1)([O-:28])=[O:27]>O>[Na+:1].[Na+:1].[Na+:1].[Na+:1].[N+:26]([C:29]1[CH:30]=[C:31]([C:38]([NH:2][C:3]2[C:4]([S:17]([O-:20])(=[O:19])=[O:18])=[CH:5][C:6]3[C:21]([CH:22]=2)=[CH:10][CH:9]=[C:8]([S:13]([O-:16])(=[O:15])=[O:14])[CH:7]=3)=[O:39])[CH:32]=[C:33]([C:35]([NH:2][C:3]2[C:4]([S:17]([O-:20])(=[O:19])=[O:18])=[CH:5][C:6]3[C:11]([CH:12]=2)=[CH:10][CH:9]=[C:8]([S:13]([O-:16])(=[O:15])=[O:14])[CH:7]=3)=[O:36])[CH:34]=1)([O-:28])=[O:27]