Ethanolamine → HCID 24998884, compound

HRID 659031Notes

Reaction equation

HRID 659031 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]3[CH:24]=[C:23](S(C)(=O)=O)[N:22]=[CH:21][N:20]=3)=[CH:14][CH:13]=2)=[O:10])=[CH:4][C:3]=1[C:29]([F:32])([F:31])[F:30].[NH2:33][CH2:34][CH2:35][OH:36]>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]3[CH:24]=[C:23]([NH:33][CH2:34][CH2:35][OH:36])[N:22]=[CH:21][N:20]=3)=[CH:14][CH:13]=2)=[O:10])=[CH:4][C:3]=1[C:29]([F:32])([F:31])[F:30]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 67523931HCID 67523931, compound

Product 1

HCID 24998884HCID 24998884, compoundYield 53.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
110 °C

Procedure

A solution of 1-(4-chloro-3-trifluoromethyl-phenyl)-3-[4-(6-methanesulfonyl-pyrimidin-4-yloxy)-phenyl]-urea (100 mg, 0.2 mmol) in dichloromethane (1 ml) and 2-aminoethanol (124 μl, 2.0 mmol) is sealed in a reaction tube and heated in the microwave at 110° C. for 15 minutes. The reaction mixture is evaporated and purified by preparative HPLC to yield 50 mg (52%) of a white powder.

Workup

  1. customThe reaction mixture is evaporated
  2. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-72b74eea649b47559c099f00b2946a1b
Source dataset
uspto-grants-2011_12
Patent number
US08080552B2

Reaction notes

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