3-(Trifluoromethyl)phenyl isocyanate → HCID 67523894, compound

Participants

Reaction Steps

A solution of 41.7 g (219 mmol) 3-trifluoromethyl-phenyl isocyanate in 50 ml dichloromethane was added within 45 min. drop by drop at 5-10° C. to a solution of 51.0 g (219 mmol) 4-(2-Methylsulfanyl-pyrimidin-4-yloxy)-phenylamine and stirring continued for 5 h at 5° C. The reaction mixture was kept in a cooling room overnight at 4° C. The formed precipitate was isolated by cold filtration and washed thrice with 40 ml ice cold dichloromethane. After an additional washing with portions of isohexane (250 ml total) the product was dried at 40° C. in vacuum to give 73.4 g (80%) 1-[4-(2-methylsulfanyl-pyrimidin-4-yloxy)-phenyl]-3-(3-trifluoromethyl-phenyl)-urea.

Provenance & Evidence