HCID 67523892, compound → HCID 24998583, compound

Participants

Reaction Steps

A mixture of 540 mg (927 mmol) 6-(3-{4-[2-(3-Hydroxy-propylamino)-pyrimidin-4-yloxy]-phenyl}-ureido)-3,3-dimethyl-2,3-dihydro-indole-1-carboxylic acid phenyl ester, 20 ml THF and 150 mg 10% Pd/C is hydrogenated at atmospheric pressure for 10 h. The catalyst is removed by filtration and the filtrate evaporated. The residue is purified by chromatography on silica (dichloromethane/methanol 95:5) and the obtained material (400 mg) stirred with dichloromethane for 1 h. the precipitate is isolated by filtration and washed with dichloromethane to give 150 mg (36%) of the title compound.

Provenance & Evidence