Methyl 3-(cyclopentyloxy)-4-methoxy-2-nitrobenzoate → Methyl 2-amino-3-(cyclopentyloxy)-4-methoxybenzoate

Participants

Role	Name	HCID	Charge
Reactant	Methyl 3-(cyclopentyloxy)-4-methoxy-2-nitrobenzoate	HCID 66781723	—
Catalyst	Palladium	HCID 23938	—
Solvent	Methanol	HCID 887	—
Product	Methyl 2-amino-3-(cyclopentyloxy)-4-methoxybenzoate	HCID 66781747	—

Reaction Steps

A mixture of methyl 3-(cyclopentyloxy)-4-methoxy-2-nitrobenzoate (750 mg, 2.54 mmol), 10% Pd/C (50% H2O, 500 mg, 0.23 mmol Pd), and methanol (10 mL) was stirred vigorously at rt under an atmosphere of H2. After 21 h, the mixture was filtered through Celite and concentrated to give methyl 2-amino-3-(cyclopentyloxy)-4-methoxybenzoate: MS (ESI): 266.5.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08080563B2
Source dataset	uspto-grants-2011_12
ORD ID	ord-fb60b902097f435781320478b2016d12
Source note	uspto-grants-2011_12