HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → Methyl 2-acetamido-3-(cyclopentyloxy)-4-methoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Methyl 2-amino-3-(cyclopentyloxy)-4-methoxybenzoate | HCID 66781747 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 2-acetamido-3-(cyclopentyloxy)-4-methoxybenzoate | HCID 66781936 | — |
Reaction Steps
A solution of methyl 2-amino-3-(cyclopentyloxy)-4-methoxybenzoate (5.54 g, 20.9 mmol), acetic anhydride (21.0 mL, 222 mmol), and dioxane (35 mL) was heated at 40° C. under N2 for 17 h and then allowed to cool to rt. Water (10 mL) was added, and after 15 min of stirring, the reaction was concentrated to give methyl 2-acetamido-3-(cyclopentyloxy)-4-methoxybenzoate: MS (ESI): 307.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08080563B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-091cd5e28ecb4d418149da275c8b725f |
| Source note | uspto-grants-2011_12 |