4-Bromo-3,5-dimethylpyridine → 8-(Cyclopentyloxy)-4-(3,5-dimethylpyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one

Participants

Role	Name	HCID	Charge
Reactant	4-Bromo-3,5-dimethylpyridine	HCID 22323246	—
Reactant	4-amino-8-(cyclopentyloxy)-7-methoxyquinolin-2(1H)-one	HCID 66781293	—
Product	8-(Cyclopentyloxy)-4-(3,5-dimethylpyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one	HCID 24851914	—

Reaction Steps

The title compound was prepared from 4-bromo-3,5-dimethylpyridine and 4-amino-8-(cyclopentyloxy)-7-methoxyquinolin-2(1H)-one (Example 1, Step 6) following the procedure outlined in Example 8. 1H NMR (400 MHz, DMSO-d6): δ 9.08 (s, 1H), 8.44 (s, 1H), 8.40 (s, 2H), 7.88 (d, 1H), 7.03 (d, 1H), 4.96 (m, 1H), 4.51 (s, 1H), 3.90 (s, 3H), 2.13 (s, 6H), 1.80-1.54 (m, 8H); MS (ESI): 380.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08080563B2
Source dataset	uspto-grants-2011_12
ORD ID	ord-2964589d2eaa4b208e00e12b95900403
Source note	uspto-grants-2011_12