HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxa-8-azaspiro(4.5)decane → 8-[(2,6-Dimethoxyphenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxa-8-azaspiro(4.5)decane | HCID 67435 | — |
| Reactant | 2,6-Dimethoxybenzaldehyde | HCID 96404 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 8-[(2,6-Dimethoxyphenyl)methyl]-1,4-dioxa-8-azaspiro[4.5]decane | HCID 68949919 | 105.1% |
Reaction Steps
A mixture of 1,4-dioxa-8-azaspiro[4,5]decane (19 mL, 0.146 mol), 2,6-dimethoxybenzaldehyde (26.7 g) and 10% Pd/C (wet, 4 g) in methanol (150 mL) was treated with hydrogen (50 psi) for 16 h. The reaction mixture was then filtered and concentrated to give 45 g of the title intermediate as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08080565B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-07cf94c060854daf8ea8b643db1d645e |
| Source note | uspto-grants-2011_12 |