HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 3-{3-[(5-Phenoxy-furan-2-carbonyl)-amino]-phenyl}-acrylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| Reactant | 5-Phenoxyfuran-2-carboxylic acid | HCID 2812790 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-{3-[(5-Phenoxy-furan-2-carbonyl)-amino]-phenyl}-acrylic acid | HCID 68413660 | — |
Reaction Steps
5-phenoxy-2-furoic acid (3) (213 mg, 1.05 mmol) was coupled to aniline (2) (200 mg, 1.05 mmol) using Method B, except that DIPEA (270 mg, 2.09 mmol) and DMF (2 mL) were used to give the title compound. Yield: 178 mg, 96%; LC/MS tr 1.65 min; HPLC Purity: 95%; MS (ES+) m/z 378 (M+H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08080567B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-b572637309d44c8aa5c4bf03177b49eb |
| Source note | uspto-grants-2011_12 |