Ethanol → HCID 68416047, compound

Participants

Reaction Steps

The ester (39) (35 mg, 0.10 mmol) was hydrolysed using Method C, except that EtOH (2 mL), THF (1 mL) and 1 M NaOH (2 mL) were used, and the reaction was stirred for 2 hours. After work-up, the crude product was purified by preparative HPLC to give the title compound. Yield: 9.8 mg, 29%; LC-MS tr 2.00 min; HPLC Purity: 97%; MS (ES+) m/z 335 (M+H); 1H NMR (400 MHz; MeOH): δ 6.95 (d, 1H), 7.05 (d, 1H), 7.35-7.55 (m, 5H), 7.65 (d, 1H), 7.85-8.00 (m, 3H), 8.30 (d, 1H)

Provenance & Evidence