Methanol → HCID 68416902, compound

Participants

Reaction Steps

The ester (51) (124 mg, 0.21 mmol) was hydrolysed using Method C, except that MeOH (1.25 mL), THF and 1M NaOH (1.25 mL) were used, and the reaction was stirred for 3 hours. The solvent was removed under a stream of nitrogen gas and the residue acidified with 1N HCl. The solid was filtered and dried to give the title compound. Yield: 91 mg, 76%; LC-MS tr 2.28 min; HPLC Purity: 94%; MS (ES+) m/z 396 (M÷H); 1H NMR (400 MHz; DMSO): δ 6.60 (d, 1H), 7.45-7.75 (m, 7H), 7.80 (d, 2H), 7.95 (m, 1H), 8.10 (d, 1H), 8.15 (s, 1H), 10.25 (s, 1H), 12.55 (br. s, 1H)

Provenance & Evidence