Ammonia → 3-(Dimethylamino)-5-nitrobenzonitrile

Temperature

220 °C

3-Bromo-N,N-dimethyl-5-nitroaniline (1.73 g, 7.06 mmol) (prepared according to the method described in J. Org. Chem. 60: 5091-5103 (2003)), pyridine (24 mL), and CuCN (1.26 g, 2.14 mmol) were added to a dry sealed tube. The mixture was heated at 220° C. with stirring for 3.5 h. The reaction mixture was allowed to cool to 100° C., poured into a flask containing a mixture of aqueous ammonia (100 mL) and water (100 mL), and extracted with EtOAc (2×100 mL). The EtOAc solution was washed with diluted ammonia solution (100 mL), water (100 mL) and brine (100 mL) successively, dried over anhydrous Na2SO4, filtered, and evaporated to dryness under reduced pressure. The residue was purified by MPLC on silica gel using a mixture of EtOAc and hexane as eluent to give 3-(dimethylamino)-5-nitrobenzonitrile (0.44 g, 33%) as an orange solid. 1H NMR (400 MHz, CDCl3): δ 7.74 (dd, 1H, J=2.0, 1.2 Hz), 7.65 (t, 1H, J=2.2 Hz), 7.11 (dd, 1H, J=2.4, 1.2 Hz), 3.10 (s, 6H).

1. customsealed tube
2. temperatureto cool to 100° C.
3. additionpoured into a flask
4. additioncontaining
5. extractionextracted with EtOAc (2×100 mL)
6. washThe EtOAc solution was washed with diluted ammonia solution (100 mL), water (100 mL) and brine (100 mL) successively
7. dry with materialdried over anhydrous Na2SO4
8. filtrationfiltered
9. customevaporated to dryness under reduced pressure
10. customThe residue was purified by MPLC on silica gel using
11. additiona mixture of EtOAc and hexane as eluent

ORD record

ord-a0fe533805b34c79828140fd889b9476

Source dataset

uspto-grants-2011_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08080568B1