HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (2-aminocyclopentyl)carbamate → cis-[2-(2-Ethyl-4-trifluoromethyl-benzoylamino)-cyclopentyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (2-aminocyclopentyl)carbamate | HCID 22667934 | — |
| Reactant | 2-Ethyl-4-(trifluoromethyl)benzoic acid | HCID 53406012 | — |
| Reactant | [(1SR,2RS)-2-(2-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoylamino)-cyclopentyl]-carbamic acid tert-butyl ester | HCID 66682567 | — |
| Product | cis-[2-(2-Ethyl-4-trifluoromethyl-benzoylamino)-cyclopentyl]-carbamic acid tert-butyl ester | HCID 66680797 | — |
Reaction Steps
The title compound, light yellow solid, MS: m/e=401.4 [(M+H)+], was prepared in accordance with the general method of intermediate N from [(1RS,2SR)-2-aminocyclopentyl-carbamic acid 1,1-dimethylethyl ester (CAS 365996-19-6) and 2-ethyl-4-(trifluoromethyl)-benzoic acid (CAS 854531-63-8).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08080541B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-ff59e0d1a7bf449bb13fbb8f1d8876a8 |
| Source note | uspto-grants-2011_12 |