HCID 58062905, compound → HCID 66682167, compound

HRID 659227Notes

Reaction equation

HRID 659227 reaction equation
[CH3:1][O:2][C:3](=[O:24])[C:4]1[C:9]([O:10][CH3:11])=[CH:8][C:7]([C:12]([F:15])([F:14])[F:13])=[CH:6][C:5]=1[O:16]CC1C=CC=CC=1>C(O)C.[Pd]>[CH3:1][O:2][C:3](=[O:24])[C:4]1[C:9]([O:10][CH3:11])=[CH:8][C:7]([C:12]([F:13])([F:15])[F:14])=[CH:6][C:5]=1[OH:16]

Participants

4

Reactant 1

HCID 58062905HCID 58062905, compound

Product 1

HCID 66682167HCID 66682167, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 60 mg (0.176 mmol) 2-benzyloxy-6-methoxy-4-trifluoromethyl-benzoic acid methyl ester in 1 ml ethanol under nitrogen at room temperature, was added 8 mg (0.0071 mmol) Pd/C 10%. The mixture was stirred at room temperature under an hydrogen atmosphere for 4 hours. The catalyst was filtered, washed with dichloromethane and the filtrate was concentrated in vacuo to provide 38 mg (y: 86.1%) of the title compound as a white solid. MS (m/e): 249.0 (M−H).

Workup

  1. filtrationThe catalyst was filtered
  2. washwashed with dichloromethane
  3. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-eba1f3c71fa246099085df199274a2f0
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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