Potassium Hydroxide → HCID 131711366, compound

HRID 65923Notes

Reaction equation

HRID 65923 reaction equation
[C:1]([C:6]1[CH:7]=[C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]=[CH:10][N:9]2[CH:18]=1)([O:3]CC)=[O:2].[OH-].[K+]>CO.O>[OH2:2].[CH:7]1[C:6]([C:1]([OH:3])=[O:2])=[CH:18][N:9]2[C:8]=1[C:17]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N:11]=[CH:10]2.[CH:7]1[C:6]([C:1]([OH:3])=[O:2])=[CH:18][N:9]2[C:8]=1[C:17]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N:11]=[CH:10]2

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 4407258Ethyl pyrrolo[1,2-c]quinazoline-2-carboxylate

Product 1

HCID 131711366HCID 131711366, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of the product of Example II (2.0 g, 0.008 m) and KOH (2.0 g, 0.036 m) in MeOH (20 ml) and H2O (20 ml) was refluxed for 1 hr. The methanol was removed under vacuum and the resulting aqueous solution was acidified with HCl (10% aqueous). When the solution became acidic, a white solid formed. It was filtered and washed well with H2O and dried, to yield 1.23 g of crude product. Crystallization from MeOH afforded the product as an off-white solid; m.p. 323°-325° C.

Workup

  1. customThe methanol was removed under vacuum
  2. customa white solid formed
  3. filtrationIt was filtered
  4. washwashed well with H2O
  5. customdried
  6. customto yield 1.23 g of crude product
  7. customCrystallization from MeOH

Sources & evidence

ORD record
ord-357d834239f84835b946d441af8069c6
Source dataset
uspto-grants-1978_12
Patent number
US04129653

Reaction notes

Loading…