2-Carbethoxy-5,6-dihydropyrrolo[1,2-c]quinazoline → HCID 22756348, compound

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Reaction Steps

To a suspension of the product of Example IV (1.5 g, 0.0062 m) in acrylonitrile (5 ml), cooled to 0°-5°, was added, dropwise, 0.4 ml of Triton B over 3 min. An exothermic reaction resulted and a brown colored solution formed. After 5 hr. of reflux, the excess of acrylonitrile was distilled in vacuo, and the semi-solid residue (0.95 g) was crystallized from methanol to afford the desired product; m.p. 102°-104° C.

Provenance & Evidence