HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrothiopyran-4-one → 2-Methoxy-N-[(1RS,2SR)-2-(tetrahydro-thiopyran-4-ylamino)-cyclohexyl]-4,6-bis-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrothiopyran-4-one | HCID 66173 | — |
| Reactant | cis-N-(2-Amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide | HCID 58062915 | — |
| Product | 2-Methoxy-N-[(1RS,2SR)-2-(tetrahydro-thiopyran-4-ylamino)-cyclohexyl]-4,6-bis-trifluoromethyl-benzamide | HCID 76683033 | — |
Reaction Steps
The title compound, white foam, MS: m/e=485.3 [(M+H)+], was prepared in accordance with the general method of example 11 from cis-N-(2-amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide (intermediate H) and tetrahydro-4H-thiopyran-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08080541B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-7527f49e794e47949af3a4a4d6c682fe |
| Source note | uspto-grants-2011_12 |