Cyclobutanone → N-((1RS,2SR)-2-Cyclobutylamino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

HRID 659261Notes

Reaction equation

[NH2:1][CH:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[NH:7][C:8](=[O:23])[C:9]1[C:14]([S:15][CH3:16])=[CH:13][C:12]([C:17]([F:20])([F:19])[F:18])=[CH:11][C:10]=1[O:21][CH3:22].[C:24]1(=O)[CH2:27][CH2:26][CH2:25]1>>[CH:24]1([NH:1][CH:2]2[CH2:6][CH2:5][CH2:4][CH:3]2[NH:7][C:8](=[O:23])[C:9]2[C:14]([S:15][CH3:16])=[CH:13][C:12]([C:17]([F:19])([F:20])[F:18])=[CH:11][C:10]=2[O:21][CH3:22])[CH2:27][CH2:26][CH2:25]1

Participants

Reactant 2

HCID 14496Cyclobutanone

HCID 66681196N-((1RS,2SR)-2-Amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide2×

Product 1

HCID 51000990N-((1RS,2SR)-2-Cyclobutylamino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

Procedure

The title compound, white solid, MS: m/e=403.4 [(M+H)+], was prepared in accordance with the general method of example 11 from N-((1RS,2SR)-2-amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (intermediate O) and cyclobutanone.

Sources & evidence

ORD record: ord-48d30d14bed64bf7964472f316140932
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08080541B2

Reaction notes

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