HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Bis(trifluoromethyl)benzamide → 2-Methoxy-6-methylsulfanyl-N-[(1RS,2SR)-2-(4-oxo-piperidin-1-yl)-cyclopentyl]-4-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Bis(trifluoromethyl)benzamide | HCID 2736099 | — |
| Reactant | 1-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide | HCID 11097568 | — |
| Reactant | N-((1RS,2SR)-2-Amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide | HCID 66681196 | — |
| Product | 2-Methoxy-6-methylsulfanyl-N-[(1RS,2SR)-2-(4-oxo-piperidin-1-yl)-cyclopentyl]-4-trifluoromethyl-benzamide | HCID 66681255 | — |
Reaction Steps
The title compound, yellow gum, MS: m/e=431.3 [(M+H)+], was prepared in accordance with the general method of intermediate J from N-((1RS,2SR)-2-amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (intermediate O) and 1-ethyl-1-methyl-4-oxo-piperidinium iodide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08080541B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-8acf14e1272d42778769c8feec2f3a64 |
| Source note | uspto-grants-2011_12 |