cis-2-Pyrrolidin-1-yl-cyclopentylamine → HCID 51000993, compound

HRID 659280Notes

Reaction equation

HRID 659280 reaction equation
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:12]1([C:15]2[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[CH:20][C:16]=2[C:17](O)=[O:18])[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[CH:23]=[C:22]([C:24]([F:25])([F:26])[F:27])[CH:21]=[CH:20][C:16]=2[C:17]([NH:11][C@@H:7]2[CH2:8][CH2:9][CH2:10][C@@H:6]2[N:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:18])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×HCID 594384852-Cyclopropyl-4-(trifluoromethyl)benzoic acid2×

Product 1

HCID 51000993HCID 51000993, compound

Procedure

The title compound, white solid, MS: m/e=367.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-cyclopropyl-4-trifluoromethyl-benzoic acid (intermediate K).

Sources & evidence

ORD record
ord-fdb2f8a6bd3f4de9b64ccc2368f7a2be
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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