cis-2-Pyrrolidin-1-yl-cyclopentylamine → cis-2-Cyclopropyl-6-ethyl-N-(2-pyrrolidin-1-yl-cyclopentyl)-benzamide

HRID 659283Notes

Reaction equation

HRID 659283 reaction equation
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:12]1([C:15]2[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][CH3:25])[C:16]=2[C:17](O)=[O:18])[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][CH3:25])[C:16]=2[C:17]([NH:11][C@@H:7]2[CH2:8][CH2:9][CH2:10][C@@H:6]2[N:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:18])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×HCID 580628792-Cyclopropyl-6-ethyl-benzoic acid2×

Product 1

HCID 51000994cis-2-Cyclopropyl-6-ethyl-N-(2-pyrrolidin-1-yl-cyclopentyl)-benzamide

Procedure

The title compound, white solid, MS: m/e=327.4 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-cyclopropyl-6-ethyl-benzoic acid (intermediate T).

Sources & evidence

ORD record
ord-1418f4dde13f4cbd883d1b0f7d853b22
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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