cis-2-Pyrrolidin-1-yl-cyclopentylamine → HCID 66680830, compound

HRID 659293Notes

Reaction equation

HRID 659293 reaction equation
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:12][O:13][C:14]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[C:19]([O:27][CH3:28])[C:15]=1[C:16](O)=[O:17]>>[CH3:28][O:27][C:19]1[CH:20]=[C:21]([C:23]([F:24])([F:25])[F:26])[CH:22]=[C:14]([O:13][CH3:12])[C:15]=1[C:16]([NH:11][CH:7]1[CH2:8][CH2:9][CH2:10][CH:6]1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:17]

Participants

3

Reactant 2

HCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×HCID 59438448HCID 59438448, compound

Product 1

HCID 66680830HCID 66680830, compound

Procedure

The title compound, yellow oil, MS: m/e=387.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2,6-dimethoxy-4-trifluoromethyl-benzoic acid (intermediate AJ).

Sources & evidence

ORD record
ord-61b498e679954766b3010ac89228b2ca
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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