4-Bromo-2-methylbenzoic acid → HCID 66681471, compound

HRID 659295Notes

Reaction equation

HRID 659295 reaction equation
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[C:15]([CH3:22])[CH:14]=1>>[Br:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([NH:11][C@@H:7]2[CH2:8][CH2:9][CH2:10][C@@H:6]2[N:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:18])=[C:15]([CH3:22])[CH:14]=1

Participants

3

Reactant 2

HCID 995704-Bromo-2-methylbenzoic acidHCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×

Product 1

HCID 66681471HCID 66681471, compound

Procedure

The title compound, white solid, MS: m/e=351.2/353.1 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 4-bromo-2-methyl-benzoic acid.

Sources & evidence

ORD record
ord-9dc6ec4b60b54c1ea9314b2614e1a37a
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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