cis-2-Pyrrolidin-1-yl-cyclopentylamine → HCID 51001236, compound

HRID 659300Notes

Reaction equation

HRID 659300 reaction equation
N1([C@H]2CCC[C@H]2N)CCCC1.[F:12][CH:13]([F:40])[O:14][C:15]1[CH:33]=[C:32]([C:34]([F:37])([F:36])[F:35])[CH:31]=[C:30]([O:38][CH3:39])[C:16]=1[C:17]([NH:19][C@H:20]1[CH2:24][CH2:23][CH2:22][C@H:21]1[N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:18]>>[F:40][CH:13]([F:12])[O:14][C:15]1[CH:33]=[C:32]([C:34]([F:37])([F:35])[F:36])[CH:31]=[C:30]([O:38][CH3:39])[C:16]=1[C:17]([NH:19][C@@H:20]1[CH2:24][CH2:23][CH2:22][C@@H:21]1[N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:18]

Participants

3

Reactant 2

HCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×HCID 66680924HCID 66680924, compound

Product 1

HCID 51001236HCID 51001236, compound

Procedure

The title compound, light yellow solid, MS: m/e=423.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-difluoromethoxy-6-methoxy-N-((1S,2R)-2-pyrrolidin-1-yl-cyclopentyl)-4-trifluoromethyl-benzamide (intermediate AT).

Sources & evidence

ORD record
ord-454d6b59376a480d90d35703f81e3145
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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