cis-2-Pyrrolidin-1-yl-cyclopentylamine → 2-Cyclobutyl-N-((cis)-2-pyrrolidin-1-yl-cyclopentyl)-4-trifluoromethyl-benzamide

HRID 659302Notes

Reaction equation

HRID 659302 reaction equation
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:12]1([C:16]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:17]=2[C:18](O)=[O:19])[CH2:15][CH2:14][CH2:13]1>>[CH:12]1([C:16]2[CH:24]=[C:23]([C:25]([F:26])([F:27])[F:28])[CH:22]=[CH:21][C:17]=2[C:18]([NH:11][C@@H:7]2[CH2:8][CH2:9][CH2:10][C@@H:6]2[N:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:19])[CH2:13][CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×HCID 594384322-Cyclobutyl-4-trifluoromethyl-benzoic acid

Product 1

HCID 666817722-Cyclobutyl-N-((cis)-2-pyrrolidin-1-yl-cyclopentyl)-4-trifluoromethyl-benzamide

Procedure

The title compound, light orange solid, MS: m/e=381.4 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-cyclobutyl-4-trifluoromethyl-benzoic acid (intermediate AP).

Sources & evidence

ORD record
ord-a58412bea3ab4c57904ad28d55b74ac3
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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