HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Cyclophosphamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Phosphoramidic dichloride, bis(2-chloroethyl)- | HCID 96271 | — |
| Reactant | Methylamino-1-phenyl-1-propanol | HCID 19933884 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Cyclophosphamide | HCID 2907 | — |
Reaction Steps
A solution of bis(2-chloroethyl)phosphoramidic dichloride (10 mmol) in ethyl acetate (100 mL) is added dropwise to a solution of commercial 3 methylamino-1-phenyl-1-propanol (10 mmol) and triethylamine (20 mmol) in ethyl acetate (100 mL) at rt. After stirring at rt for 3 days, the salts are filtered off and the combined filtrates are concentrated under vacuum. The crude product is purified by column chromatography on silica.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08080536B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-ba24910390c54d239897abdfb963ae7b |
| Source note | uspto-grants-2011_12 |