HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-Bromo-5-chloro-6-sulfamoyl-1-indanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 6-chloro-3-oxo-2,3-dihydro-1H-indene-5-sulfonamide | HCID 22756384 | — |
| Reactant | Sodium Bisulfite | HCID 23665763 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Bromo-5-chloro-6-sulfamoyl-1-indanone | HCID 22756397 | — |
Reaction Steps
0.1 Milliliter of 48% aqueus HBr is added to a suspension of 52 g (0.21 mole) of 5-chloro-6-sulfamoyl-1-indanone in 530 ml of glacial acetic acid. Subsequently a solution of 34.0 g (0.21 mole) of bromine in 160 ml of glacial acetic acid is added dropwise. The mixture is stirred for another 1.5 hours, and is then poured into a solution of 4.5 g of NaHSO3 in 2 of ice water. The 2-bromo-5-chloro-6sulfamoyl-1-indanone which crystallizes after stirring for some time is filtered off with suction and is washed with water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04129656 |
| Source dataset | uspto-grants-1978_12 |
| ORD ID | ord-1cd6040e538a49d69753b1c347b4f1bb |
| Source note | uspto-grants-1978_12 |