Bromine → 6-Benzylsulfamoyl-2-bromo-5-chloro-1-indanone

HRID 65937Notes

Reaction equation

HRID 65937 reaction equation
[CH2:1]([NH:8][S:9]([C:12]1[CH:20]=[C:19]2[C:15]([CH2:16][CH2:17][C:18]2=[O:21])=[CH:14][C:13]=1[Cl:22])(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:23]Br>C(O)(=O)C>[CH2:1]([NH:8][S:9]([C:12]1[CH:20]=[C:19]2[C:15]([CH2:16][CH:17]([Br:23])[C:18]2=[O:21])=[CH:14][C:13]=1[Cl:22])(=[O:11])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 227563726-Benzylsulfamoyl-5-chloro-1-indanone

Product 1

HCID 227563716-Benzylsulfamoyl-2-bromo-5-chloro-1-indanone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

According to Example 1 e), 10.05 g (30 mmoles) of 6-benzylsulfamoyl-5-chloro-1-indanone and 4.8 g (30 mmoles) of bromine in a total of 110 ml of glacial acetic acid yield the substance having a melting point of from 159° to 161° C. which after reprecipitation from a mixture of ethyl acetate and petroleum ether has a melting point in the range of from 176° to 178° C.

Workup

  1. customyield the substance
  2. customof from 159° to 161° C. which
  3. customafter reprecipitation
  4. additionfrom a mixture of ethyl acetate and petroleum ether
  5. customof from 176° to 178° C.

Sources & evidence

ORD record
ord-3e4523ab0b9d414fb5d47053c1926807
Source dataset
uspto-grants-1978_12
Patent number
US04129656

Reaction notes

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