7-iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one → HCID 57885878, compound

HRID 659408Notes

Reaction equation

HRID 659408 reaction equation
[I:1][C:2]1[CH:12]=[N:11][C:5]2[NH:6][CH2:7][C:8](=[O:10])[NH:9][C:4]=2[CH:3]=1.Br[CH:14]([C:16]1[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:17]=1[F:24])[CH3:15]>>[I:1][C:2]1[CH:12]=[N:11][C:5]2[NH:6][CH2:7][C:8](=[O:10])[N:9]([CH:14]([C:16]3[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:17]=3[F:24])[CH3:15])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 448291147-iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-oneHCID 578858611-(1-Bromoethyl)-2,4,5-trifluorobenzene

Product 1

HCID 57885878HCID 57885878, compound

Procedure

7-Iodo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (297 mg) was alkylated with 1-(1-bromoethyl)-2,4,5-trifluorobenzene as in General Procedure 1 to give the title compound.

Sources & evidence

ORD record
ord-e07b6dfa281c4bcf9c67dd758d1232ae
Source dataset
uspto-grants-2011_12
Patent number
US08080561B2

Reaction notes

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