Bromine → 2-Bromo-5-chloro-2-methyl-6-sulfamoyl-1-indanone

HRID 65941Notes

Reaction equation

HRID 65941 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[S:11](=[O:14])(=[O:13])[NH2:12])[C:7](=[O:15])[CH:6]([CH3:16])[CH2:5]2.[Br:17]Br>C(O)(=O)C>[Br:17][C:6]1([CH3:16])[CH2:5][C:4]2[C:8](=[CH:9][C:10]([S:11](=[O:13])(=[O:14])[NH2:12])=[C:2]([Cl:1])[CH:3]=2)[C:7]1=[O:15]

Participants

4

Reactant 2

HCID 24408BromineHCID 227564065-Chloro-2-methyl-6-sulfamoyl-1-indanone

Product 1

HCID 227564072-Bromo-5-chloro-2-methyl-6-sulfamoyl-1-indanone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

According to Example 1 (e), 9.7 g (0.037 mole) of 5-chloro-2-methyl-6-sulfamoyl-1-indanone and 5.97 g (0.037 mole) of bromine in a total of 95 ml of glacial acetic acid yield 2-bromo-5-chloro-2-methyl-6-sulfamoyl-1-indanone, which melts at a temperature of from 136° to 138° C. after reprecipitation from a mixture of ethyl acetate and petroleum ether.

Sources & evidence

ORD record
ord-ad2d86e3e0414535845501526341a908
Source dataset
uspto-grants-1978_12
Patent number
US04129656

Reaction notes

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