4-Ethoxycarbonylphenylboronic acid → HCID 57885909, compound

HRID 659479Notes

Reaction equation

HRID 659479 reaction equation
[Cl:1][C:2]1[C:7]([CH2:8][N:9]2[CH2:14][CH2:13][NH:12][C:11]3[N:15]=[CH:16][C:17](I)=[CH:18][C:10]2=3)=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:20]([O:22][C:23]([C:25]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27][CH:26]=1)=[O:24])[CH3:21]>>[CH2:20]([O:22][C:23](=[O:24])[C:25]1[CH:30]=[CH:29][C:28]([C:17]2[CH:16]=[N:15][C:11]3[NH:12][CH2:13][CH2:14][N:9]([CH2:8][C:7]4[C:2]([Cl:1])=[N:3][CH:4]=[CH:5][CH:6]=4)[C:10]=3[CH:18]=2)=[CH:27][CH:26]=1)[CH3:21]

Participants

3

Reactant 2

HCID 27343504-Ethoxycarbonylphenylboronic acidHCID 57886072HCID 57886072, compound

Product 1

HCID 57885909HCID 57885909, compound

Procedure

1-(2-Chloropyridin-3-ylmethyl)-7-iodo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine (389 mg) was reacted with (4-ethoxycarbonylphenyl) boronic acid as in General Procedure 4B to give the title compound as a yellow solid. LCMS: m/z=409.34 (M+H+).

Sources & evidence

ORD record
ord-8264693cefb74046ac9c16cdfa016e2a
Source dataset
uspto-grants-2011_12
Patent number
US08080561B2

Reaction notes

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