1-[2-(Trifluoromethyl)phenyl]piperazine → (3-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}phenyl)-{4-[2-(trifluoromethyl)phenyl]piperazin-1-yl}methanone

Participants

Role	Name	HCID	Charge
Reactant	1-[2-(Trifluoromethyl)phenyl]piperazine	HCID 2777670	—
Reactant	3-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid	HCID 58327807	—
Product	(3-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}phenyl)-{4-[2-(trifluoromethyl)phenyl]piperazin-1-yl}methanone	HCID 58327869	—

Reaction Steps

3-{1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid was reacted with 1-[2-(trifluoromethyl)phenyl]piperazine as in General Procedure 10 to give the title compound. LCMS: m/z=659.99 (M+H+); retention time=1.1 minutes.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08080561B2
Source dataset	uspto-grants-2011_12
ORD ID	ord-278ba9c6eacb4dd08602c85db6547716
Source note	uspto-grants-2011_12