4-(Piperazin-1-yl)thieno[3,2-d]pyrimidine → HCID 58327852, compound

HRID 659497Notes

Reaction equation

HRID 659497 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:31])([F:30])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=3)[C:21](O)=[O:22])=[CH:17][C:9]1=2.[N:32]1[C:37]2[CH:38]=[CH:39][S:40][C:36]=2[C:35]([N:41]2[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)=[N:34][CH:33]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:29])([F:31])[F:30])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:19]=[C:20]([C:21]([N:44]4[CH2:45][CH2:46][N:41]([C:35]5[C:36]6[S:40][CH:39]=[CH:38][C:37]=6[N:32]=[CH:33][N:34]=5)[CH2:42][CH2:43]4)=[O:22])[CH:24]=[CH:25][CH:26]=3)=[CH:17][C:9]1=2

Participants

3

Reactant 2

HCID 27604284-(Piperazin-1-yl)thieno[3,2-d]pyrimidineHCID 583278073-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid

Product 1

HCID 58327852HCID 58327852, compound

Procedure

3-{1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid was reacted with 1-(4-thieno[3,2-d]pyrimidinyl)piperazine as in General Procedure 10 to give the title compound. LCMS: m/z=649.98 (M+H+); retention time=0.65 minutes.

Sources & evidence

ORD record
ord-a555360b380342ca9e61820de891b943
Source dataset
uspto-grants-2011_12
Patent number
US08080561B2

Reaction notes

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