HRID659499

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID231905

4-methoxy BZP

C12H18N2O

结构：O=C(O)c1cccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)c1

HCID58327807

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CN2CCN(C(=O)c3cccc(-c4cnc5c(c4)N(Cc4cc(Cl)ccc4C(F)(F)F)CCN5)c3)CC2)cc1

HCID67091858

未命名化合物

PROCEDURE

实验过程

3-{1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid was reacted with 1-(4-methoxybenzyl)piperazine as in General Procedure 10 to give the title compound. LCMS: m/z=636.01 (M+H+); retention time=0.62 minutes.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e41a905f8f1e41058335c28014ed3aec
来源数据集: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08080561B2
来源说明: uspto-grants-2011_12

反应 SMILES

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:31])([F:30])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=3)[C:21]([OH:23])=O)=[CH:17][C:9]1=2.[CH3:32][O:33][C:34]1[CH:46]=[CH:45][C:37]([CH2:38][N:39]2[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]2)=[CH:36][CH:35]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:30])([F:31])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:19]=[C:20]([C:21]([N:42]4[CH2:41][CH2:40][N:39]([CH2:38][C:37]5[CH:45]=[CH:46][C:34]([O:33][CH3:32])=[CH:35][CH:36]=5)[CH2:44][CH2:43]4)=[O:23])[CH:24]=[CH:25][CH:26]=3)=[CH:17][C:9]1=2