4-(Trifluoromethoxy)benzylamine → HCID 86618196, compound

HRID 659506Notes

Reaction equation

HRID 659506 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:31])([F:30])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=3)[C:21](O)=[O:22])=[CH:17][C:9]1=2.[F:32][C:33]([F:44])([F:43])[O:34][C:35]1[CH:42]=[CH:41][C:38]([CH2:39][NH2:40])=[CH:37][CH:36]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:29])([F:31])[F:30])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=3)[C:21]([NH:40][CH2:39][C:38]3[CH:41]=[CH:42][C:35]([O:34][C:33]([F:43])([F:44])[F:32])=[CH:36][CH:37]=3)=[O:22])=[CH:17][C:9]1=2

Participants

3

Reactant 2

HCID 5718464-(Trifluoromethoxy)benzylamineHCID 583278073-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid

Product 1

HCID 86618196HCID 86618196, compound

Procedure

3-{1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid was reacted with 4-(trifluoromethoxy)benzylamine as in General Procedure 10 to give the title compound. LCMS: m/z=620.94 (M+H+); retention time=1.04 minutes.

Sources & evidence

ORD record
ord-bfe2888642994e41bcbef7bf8c885c04
Source dataset
uspto-grants-2011_12
Patent number
US08080561B2

Reaction notes

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