1-Phenyl-1,3,8-triazaspiro(4.5)decan-4-one → HCID 58327793, compound

HRID 659543Notes

Reaction equation

HRID 659543 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:31])([F:30])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][CH:19]=3)=[CH:17][C:9]1=2.[C:32]1([N:38]2[C:42]3([CH2:47][CH2:46][NH:45][CH2:44][CH2:43]3)[C:41](=[O:48])[NH:40][CH2:39]2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:31])([F:30])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:26]=[CH:25][C:21]([C:22]([N:45]4[CH2:44][CH2:43][C:42]5([N:38]([C:32]6[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=6)[CH2:39][NH:40][C:41]5=[O:48])[CH2:47][CH2:46]4)=[O:24])=[CH:20][CH:19]=3)=[CH:17][C:9]1=2

Participants

3

Reactant 2

HCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-oneHCID 469067184-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid

Product 1

HCID 58327793HCID 58327793, compound

Procedure

4-{1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid was reacted with 1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one as in General Procedure 10 to give the title compound. LCMS: m/z=661.03 (M+H+); retention time=0.86 minutes.

Sources & evidence

ORD record
ord-13aa3a6afcd74398b6b1e6646ab2706f
Source dataset
uspto-grants-2011_12
Patent number
US08080561B2

Reaction notes

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