1-Piperazinylpyrazine → (4-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}phenyl)-(2,3,5,6-tetrahydro[1,2']bipyrazinyl-4-yl)methanone

Participants

Role	Name	HCID	Charge
Reactant	1-Piperazinylpyrazine	HCID 2734639	—
Reactant	4-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid	HCID 46906718	—
Product	(4-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}phenyl)-(2,3,5,6-tetrahydro[1,2']bipyrazinyl-4-yl)methanone	HCID 58327799	—

Reaction Steps

4-{1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid was reacted with 2-(1-piperazinyl)pyrazine as in General Procedure 10 to give the title compound. LCMS: m/z=593.98 (M+H+); retention time=0.79 minutes.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08080561B2
Source dataset	uspto-grants-2011_12
ORD ID	ord-6eadc21fef8946d9a15052c635d77aef
Source note	uspto-grants-2011_12