(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine → HCID 58327926, compound

HRID 659593Notes

Reaction equation

HRID 659593 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:31])([F:30])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=3)=[CH:17][C:9]1=2.[N:32]1([CH2:37][C@@H:38]2[CH2:42][CH2:41][CH2:40][NH:39]2)[CH2:36][CH2:35][CH2:34][CH2:33]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:30])([F:31])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:19]=[CH:20][C:21]([C:22]([N:39]4[CH2:40][CH2:41][CH2:42][C@H:38]4[CH2:37][N:32]4[CH2:36][CH2:35][CH2:34][CH2:33]4)=[O:23])=[CH:25][CH:26]=3)=[CH:17][C:9]1=2

Participants

3

Reactant 2

HCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 469067184-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid

Product 1

HCID 58327926HCID 58327926, compound

Procedure

4-{1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid was reacted with (S)-2-(1-pyrrolidinylmethyl)pyrrolidine as in General Procedure 10 to give the title compound. LCMS: m/z=583.95 (M+H+); retention time=0.58 minutes.

Sources & evidence

ORD record
ord-34fbd8704ea0471aad5031b7a8a45c23
Source dataset
uspto-grants-2011_12
Patent number
US08080561B2

Reaction notes

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