HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Imiquimod
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 4-(N-benzylamino)-1-isobutyl-1H-imidazo(4,5-c)quinoline | HCID 15606307 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Imiquimod | HCID 57469 | — |
Reaction Steps
1.0 gram of 4-(N-benzylamino)-1-isobutyl-1H-imidazo(4,5-c)quinoline is added to 10 mL of ethanol, followed by the addition of 0.03 gram triethylamine and 0.2 gram of Pearlman's catalyst (20% Pd(OH)2/C). The mixture is stirred at 40° C. under 1 atm hydrogen until completion. The mixture is then filtered through Celite® and the filtrate, containing 4-amino-1-isobutyl-1H-imidazo(4,5-c)quinoline (imiquimod), is concentrated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08080662B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-772d01cce76f408b81eb16d64128b880 |
| Source note | uspto-grants-2011_12 |