Ethyl 4-chloroacetoacetate → Ethyl {2-[4-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}acetate

Participants

Reaction Steps

4-Chloro-3-oxo-butyric acid ethyl ester was added to a suspension of (4-trifluoromethyl-phenyl)-thiourea (3 grams), obtained in step (ii), in ethanol (20 mL) and refluxed for about 12 hrs. The reaction mixture was cooled and the solid obtained was filtered and dried to give the pure product (4.1 grams).

Provenance & Evidence