HCID 24871998, compound → HCID 68444531, compound

HRID 659749Notes

Reaction equation

HRID 659749 reaction equation
ClC1C=C(C2OC([NH:13][C:14]3[CH:19]=[C:18]([CH2:20][O:21][CH2:22][CH3:23])[CH:17]=[CH:16][C:15]=3[CH3:24])=NC=2)C=CN=1.Cl[C:26]1[O:27][C:28]([C:31]2[C:36]([Cl:37])=[CH:35][N:34]=[CH:33][C:32]=2[Cl:38])=[CH:29][N:30]=1.ClC1OC(C2C=CN=C(Cl)C=2)=CN=1>>[Cl:38][C:32]1[CH:33]=[N:34][CH:35]=[C:36]([Cl:37])[C:31]=1[C:28]1[O:27][C:26]([NH:13][C:14]2[CH:19]=[C:18]([CH2:20][O:21][CH2:22][CH3:23])[CH:17]=[CH:16][C:15]=2[CH3:24])=[N:30][CH:29]=1

Participants

4

Reactant 3

HCID 24871998HCID 24871998, compoundHCID 68443227HCID 68443227, compoundHCID 86633026HCID 86633026, compound

Product 1

HCID 68444531HCID 68444531, compoundYield 81%

Procedure

The same procedure outlined above in the preparation of 5-(2-chloropyridin-4-yl)-N-(5-(ethoxymethyl)-2-methylphenyl) oxazol-2-amine was used. However 2-chloro-5-(3,5-dichloropyridin-4-yl)oxazole was used instead 2-chloro-5-(2-chloropyridin-4-yl)oxazole. Yield=81%.

Sources & evidence

ORD record
ord-8be6caf670de44f4b9e6158fa9308033
Source dataset
uspto-grants-2011_12
Patent number
US08080669B2

Reaction notes

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