Formaldehyde → HCID 10171518, compound

Participants

Reaction Conditions

Reaction Steps

In a 1 L stainless-steel autoclave, 100 g (0.657 mol) of 1,4-dihydroxy-2,3,5-trimethylbenzene, 110 g of an aqueous formalin solution (formaldehyde 37 wt %, water 56 wt %, and methanol 7 wt %), and 330 g (3.296 mol) of methyl methacrylate were placed. The mixture was allowed to react at 180° C. for 3 hours under stirring. After the mixture was cooled to 40° C., precipitated crystals were filtered, and rinsed twice with 200 g of methanol. The collected crystals were dried to obtain the aimed methyl 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylate (hereinafter, referred to as CCM) in an amount of 135 g (0.478 mol as CCM, yield: 72.6%, chemical purity: 93.5%).

Provenance & Evidence